Cardiovascular disease is a significant health concern that results in more fatalities in the United States than any other ailment. This condition impacts the heart and blood vessels, potentially resulting in life-threatening outcomes like heart attacks and strokes. Managing cardiovascular disease from a functional perspective necessitates a thorough evaluation of genetic markers, lifestyle risk factors, and cardiovascular biomarkers. Examining inflammation, low nitric oxide levels, high homocysteine, lipoprotein (a), oxidative stress, and exposure to toxic metals like arsenic, lead, or mercury are several examples of a detailed investigation to determine your probability of developing cardiovascular disease. Early identification and management of cardiovascular disease risks can identify potential issues and a functional integrative plan can be implemented to result in a better prognosis and an extended, healthier life.